2010 : Italian Health Ministry, Grant Ricerca Finalizzata
2008: Italian Research Ministry , PRIN Grant
Professional Memberships
• Italian Society of Biochemistry and Molecular Biology
• Consorzio Interuniversitario ‘‘Istituto Nazionale Biostrutture e Biosistemi’’ (I.N.B.B.),
Rome, Italy
Research field
My research group investigates the role of the alteration of the homeostasis of the transition metal copper in neurodegeneratio n, correlated with m itochondrial function impairment and oxidative stress. Alteration of copper homeostasis and GABA metabolism in Alzheimer’s disease are currently under study , focused to understand whether these aspects are involved in Alzheimer’s etiology, and may represent early markers of this disease as well as therapeutical targets . Cell models of neurodegeneration as well a s patients’ specimens are examined .
Publications
• C.R .Capo, J.Z. Pedersen, M. Falconi, L.Rossi (2017) “ Oleuropein shows copper complexing properties and noxious effect on cultured SH – SY5Y neuroblastoma cells depending on cell copper content” J Trace Elem . Med . Biol . . 44,225 – 232. do i: 10.1016/j.jtemb.2017.08.002.
• S. Leo, C. Capo, B.M .Ciminelli, F. Iacovelli, G. Menduti, S. Funghini, MA Donati, M Falconi, L Rossi, P Malaspina (2017) “ SSADH deficiency in an Italian family: a novel ALDH5A1 gene mutation affec ting the succinic semialdehyde substrate binding site ” Metab .
Brain Dis. 32, 1383 – 1388. doi: 10.1007/s11011 – 017 – 0058 – 5.
• R . Squitti, M . Siotto, M . Arciello, L . Rossi .
(2016) “ Non – ceruloplasmin bound copper and ATP7B gene variants in Alzheimer’s dis ease ” Metallomics 8 , 863 – 73. doi10.1039/c6mt00101g .
• N . D’Ambrosi, L . Rossi (2015) “ Copper at synapse: Release, binding and m odulation of neurotransmission” Neurochem . Int . 90, 36 – 45. do i: 10.1016/j.neuint.2015.07.006
• M . L . De Benedetto , C . Capo A. Ferri , C . Valle, R . Polimanti, M . T . Carrì, L . Rossi (2014).
“ Glutaredoxin 1 is a major player in copper me tabolism in neuroblastoma cells” Biochim. Biophys. Acta 1840, 255 – 261. doi: 10.1016/j.bbagen.2013.09.008.
• L . Rossi , C . Valle, M . T . Carrì (2012).
“ Altered gene expression, mitochondrial damage and oxidative stress: converging routes in motor neuron degeneration ” Int . J . Cell Biol . 2012:908724. doi: 10.1155/2012/908724 .
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M . Arciello, C . R . Capo, S . D’annibale, M . Cozzolino, A . Ferri, M . T . Carrì, L. Rossi (2011) .
“ Copper depletion increases the mitochondrial – associated SOD1 in neuronal cells ” Biometals 24, 269 – 278, ISSN: 0966 – 0844, doi: 10.1007/s10534 – 010 – 9392 – 3 .
• M. Arciello, C.R. Capo, M. Cozzolino, A. Ferri, M. Nencini, M.T. Carrì, L. Rossi (2010) “ Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC – 34 cells is independent from copper availability but is because of nitric oxide” J . Neurochem . 112, 183 – 192. doi: 10.1111/j.1471 – 4159.2009.06441.
• L. Rossi , S. Mazzitelli, M. Arciello, C.R. Capo, G. Rotilio (2008).
“ Benefits from dietary polyphenols for brain aging and Alzheimer’s disease ” Neurochem . Res. , 33, 2390 – 2400, doi: 10.1007/s11064 – 008 – 9696 – 7 .
• C . R . Capo, M . Arciello, L . Calabrese, R . Squitti, P . M . , Rossini , L. Rossi (2008).
“ Features of ceruloplasmin in the cerebrospinal fluid of Alzheimer’s disease patients” Biometals , 2 1, 367 – 372, doi: 10.1007/s10534 – 007 – 9125 – 4 .
